All your knowledge does not help, if it prevents you from discovering new things. Especially experts with great knowledge and experience tend to use behavior that proved successful in the past, to tackle new problems. Although it helped them to be successful, exactly this can be a reason that they will fail in the future.
Alfred Sloan, who ran General Motors from 1923 to 1956, was onto something when he said at a meeting, "Gentlemen, I take it that we are all in complete agreement on the decision here. Then, I propose that we postpone further discussion ... to give ourselves time to develop disagreement and perhaps gain some understanding of what the decision is all about." (from The Innovation Killer: How What We Know Limits What We Can Imagine... And What Smart Companies Are Doing About It)
There are many examples (Polaroid, American tire industry, disk drive industry... Managing Strategic Innovation and Change - A Collection of Readings), where gathered expertise proved as an obstacle for the coming changes.
A BPX shall therefore always consider that new business processes and requirements might challenge existing knowledge and understanding. In order to institutionalize this, a BPX must make sure that diverse teams are formed and zero-gravity thinkers The Innovation Killer) invited to projects to question and challenge the status-quo.