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The SAP Community team.
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Windows Server 2008 Antivirus exclusions

%windir%\SoftwareDistribution\Datastore\Datastore.edb
%windir%\SoftwareDistribution\Datastore\Logs\Edb*.log
%windir%\SoftwareDistribution\Datastore\Logs\Edb.chk
%windir%\SoftwareDistribution\Datastore\Logs\tmp.edb
%windir%\SoftwareDistribution\Datastore\Logs\Edbres00001.jrs
%windir%\SoftwareDistribution\Datastore\Logs\Edbres00002.jrs
%windir%\softwaredistribution*.cab
%windir%\SoftwareDistribution\Datastore\Logs\Res1.log
%windir%\SoftwareDistribution\Datastore\Logs\Res2.log
%windir%\security*.edb
%windir%\security*.sdb
%windir%\security*.log
%windir%\security*.chk
%windir%\security\database*.sdb
%windir%\system32\ccm\cache*.cab
%allusersprofile%\NTUser.pol
%Systemroot%\system32\GroupPolicy**\registry.pol

Microsoft SQL Server Antivirus exclusions

SQL Server data files:
.mdf
.ldf
.ndf
SQL Server backup files:
.bak
.trn

SQL Server 2008 R2

•%ProgramFiles%\Microsoft SQL Server\MSSQL10_50.<Instance Name>\MSSQL\Binn\SQLServr.exe
•%ProgramFiles%\Microsoft SQL Server\MSSQL10_50.<Instance Name>\Reporting Services\ReportServer\Bin\ReportingServicesService.exe
•%ProgramFiles%\Microsoft SQL Server\MSSQL10_50.<Instance Name>\OLAP\Bin\MSMDSrv.exe

SAP Antivirus exclusions

\usr\sap\
\SAPDB\
SAPSprint.exe
lsagent.exe

SAP Notes for Virus Scanner software

SAP Note 106267  - Virus scanner software on Windows

SAP Note 1625003 - Which files and directories should be a part of Antivirus exclusion list in BI 4.0